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Saami K. Yazdani, PhD

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University of South Alabama Department of Mechanical Engineering 150 Jaguar Drive, Shelby Hall, Room 3123 Mobile, AL T: , F: , M:
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University of South Alabama Department of Mechanical Engineering 150 Jaguar Drive, Shelby Hall, Room 3123 Mobile, AL T: , F: , M: EDUCATION Wake Forest University School of Medicine 2008 Doctorate of Philosophy, Biomedical Engineering Winston-Salem, NC Department of Biomedical Engineering / Wake Forest Institute for Regenerative Medicine Dissertation: Bioreactor Preconditioning of Tissue Engineered Blood Vessels Virginia Tech 2004 Master of Science, Engineering Mechanics Blacksburg, VA Department of Engineering Science and Mechanics Thesis: Geometry Induced Flow Disturbances Virginia Tech 2001 Bachelor of Science, Engineering of Science and Mechanics Blacksburg, VA Department of Engineering Science and Mechanics EXPERIENCE Assistant Professor University of South Alabama, Department of Mechanical Engineering August present Mobile, AL Post-Doctoral Research Scientist CVPath Institute, Inc. Gaithersburg, MD Conducted pathologic assessments of catheter-based clinical devices for the purpose of understanding mode of failures related to design and implementation Developed in vitro models to analyze the biological impact of varying design criteria of coronary stents Performed histological and molecular assessments of vulnerable lesions in post-mortem material to better understand events leading to sudden cardiac death Initiated collaboration with NIH and FDA which has lead to multiple research projects and publications submissions Served as project manager for multiple contract-based preclinical studies. Assisted in budget planning for future work load projections Graduate Research Assistant Wake Forest University, Department of Biomedical Engineering Winston-Salem, NC Wake Forest Institute for Regenerative Medicine (WFIRM) Designed, built and successfully implemented a novel blood vessel bioreactor Successfully developed dual seeded tissue engineered blood vessels (TEBV) ; the first step to toward an alternate solution for synthetic grafts used for dialysis patients Computed Finite Element Analysis of stented arteries Developed a novel in vitro system for evaluation of stent-induced cell proliferation Graduate Teaching Assistant Summer 2003 Virginia Tech, The Center for the Enhancement for Engineering Diversity Blacksburg, VA advisor: Tremayne Waller Taught freshmen engineering students fundamental concepts in mathematics and physics through interactive learning Graduate Research Assistant Virginia Tech, Department of Engineering Science and Mechanics Blacksburg, VA advisor: Pavlos Vlachos, PhD Performed analysis on fluid dynamics of arterial flow in control animals Tested and quantified stent-induced flow disturbances PUBLICATIONS Peer Reviewed Journal Articles 1. Otsuka F, Cheng Q, Yahagi K, Acampado E, Sheehy A, Yazdani SK, Sakakura K, Euller K, Perkins LE, Kolodgie FD, Virmani R, Joner M. Acute Thrombogenicity of a Durable Polymer Everolimus-Eluting Stent Relative to Contemporary Drug-Eluting Stents With Biodegradable Polymer Coatings Assessed Ex Vivo in a Swine Shunt Model. JACC Cardiovasc Interv. 2015;8(9): Malve M, Gharib AM, Yazdani SK, Finet G, Martinez MA, Pettigrew R, Ohayon J. Tortuosity of coronary bifurcation as a potential local risk factor for atherosclerosis: CFD steady state study based on in vivo dynamic CT measurements. Ann Biomed Eng. 2015; 43(1): Yazdani SK, Pacheco E, Nakano M, Otsuka F, Naisbitt S, Kolodgie FD, Ladich E, Rousselle S, Virmani R. Vascular, downstream, and pharmacokinetic responses to treatment with a low dose drug-coated balloon in a swine femoral artery model. Catheter Cardiovasc Interv. 2014; 83(1): Bouvier A, Deleaval F, Doyley MM, Yazdani SK, Finet G, Le Floc'h S, Cloutier G, Pettigrew RI, Ohayon J. A direct vulnerable atherosclerotic plaque elasticity reconstruction method based on an original material-finite element formulation: theoretical framework. Phys Med Biol. 2013; 58(23): Yazdani SK, Nakano M, Otsuka F, Kolodgie FD, Virmani R. Animal models of vascular repair and reendothelialization. Rev Esp Cardiol Supl. 2013; 13(E): Yazdani SK, Sheehy A, Nakano M, Nakazawa G, Vorphal M, Outsuka F, Donn RS, Perkins LE, Simonton CA, Kolodgie FD, Virmani R. Preclinical evaluation of 2nd generation everolimus and zotarolimus eluting coronary stents. Journal of Invasive Cardiology. 2013; 25 (8): Deleaval F, Bouvier A, Finet G, Cloutier G, Yazdani SK, Le Floc'h S, Clarysse P, Pettigrew RI, Ohayon J. The Intravascular Ultrasound Elasticity-Palpography Technique Revisited: A reliable Tool for the in vivo Detection of Vulnerable Coronary Atherosclerotic Plaques. Ultrasound in Medicine & Biology. 2013; 39(8): Yazdani SK, Otsuka F, Nakano M, Ladich E, Virmani R. Pathology of Saphenous Vein Grafts. Interventional Cardiology Clinics. 2013; 2(2): Habib A, Karmali V, Polavarapu R, Akahori H, Nakano M, Yazdani S, Otsuka F, Pachura K, Davis T, Narula J, Kolodgie FD, Virmani R, Finn AV. Metformin impairs vascular endothelial recovery after stent placement in the setting of local eluted mammalian target of rapamycin inhibitors via s6 kinase-dependent inhibition of cell proliferation. JACC. 2013; 61 (9): Le Floc'h S, Cloutier G, Saijo Y, Finet G, Yazdani SK, Deleaval F, Rioufol G, Pettigrew RI, Ohayon J. A Four-Criterion Selection Procedure for Atherosclerotic Plaque Elasticity Reconstruction Based on In Vivo Coronary Intravascular Ultrasound Radial Strain Sequences. Ultrasound in Medicine & Biology. 2012; 38(12): Tillman BW, Yazdani SK, Neff LP, Corriere MA, Christ GJ, Soker S, Geary RL, Yoo JJ. Bioengineered Vascular Access Maintains Structural Integrity in Response to Arteriovenous Graft Flow and Repeated Needle Puncture. Journal of Vascular Surgery. 2012; 56(3): Yazdani SK, Farb A, Nakano M, Vorpahl M, Ladich E, Finn AV, Kolodgie FD, Virmani R. Pathology of drug-eluting versus bare metal stents in saphenous vein graft lesions. JACC Cardiovascular Intervention. 2012; 5(6): Otsuka F, Finn AV, Yazdani SK, Nakano M, Kolodgie FD, Virmani R. The Importance of the Endothelium in Atherothrombosis and Coronary Stenting. Nature Reviews Cardiology. 2012; 9(8): of 9 14. Yazdani SK, Nakano M, Otsuka F, Kolodgie FD, Virmani R. Accelerating Endothelialization of Coronary Stents by Capturing Circulating Endothelial Progenitor Cells with CD34 antibody. Interventional Cardiology. 2012;4(2): Yazdani SK, Kolodgie FD, Virmani R. Ex vivo and preclinical assessment of an endothelial progenitor cell capturing bioengineering stent. Minerva Cardioangiologica. 2012; 60(1): Nakano M, Vorpahl M, Otsuka F, Taniwaki M, Yazdani SK, Finn AV, Ladich ER, Kolodgie FD, Virmani R. Ex vivo assessment of vascular response to coronary stents by optical frequency domain imaging. JACC Cardiovascular Imaging. 2012; 5(1): Finn AV, Nakano M, Polavarapu R, Karmali V, Zhao X, Yazdani S, Davis T, Habib A, Saeed O, Narula J, Kolodgie FD, Virmani R. Hemoglobin directs macrophage differentiation and determines lipid uptake in human atherosclerotic plaques. Journal of American College of Cardiology. 2012; 59(2): Larsen K, Cheng C, Tempel D, Parker S, Yazdani S, den Dekker WK, Houtgraaf JH, de Jong R, Hoor SS, Ligtenberg E, Kolodgie FD, Serruys PW, Virmani R, Duckers HJ. Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bioengineered stent in human ex vivo shunt and rabbit denudation model. European Heart Journal. 2012; 33(1): Otsuka F, Nakano M, Yazdani SK, Ladich E, Kolodgie F, Virmani R. Pathology of fist-generation drug eluting stents. Interventional Cardiology. 2011; 6(1): Yazdani SK, Vorpahl M, Nakano M, Shih-Horng S, Kolodgie FD, Virmani R. In vitro and in vivo characterization of biodegradable polymer-based drug eluting stent. Euro Intervention. 2011; 7(7): Sheehy A, Hsu S, Sinn I, Tai J, Kolodgie FD, Nakazawa G, Yazdani SK, Quee SC, Virmani R, Polyakov I. Vascular response to coronary artery stenting in mature and juvenile swine. Cardiovascular Revascularization Medicine. 2011; 12(6): Ohayon J, Gharib AM, Garcia A, Heroux J, Yazdani SK, Valve M, Tracqui P, Martinez MA, Doblare M, Finet G, Pettigrew RI. Is Arterial Wall-Strain Stiffening an Additional Process Responsible for Atherosclerosis in Coronary Bifurcations: in vivo Study Based on Dynamic CT and MRI. American Journal of Physiology Heart and Circulatory Physiology. 2011; 301(3): H Nakazawa G, Otsuka F, Nakano M, Vorpahl M, Yazdani SK, Ladich E, Kolodgie FD, Finn AV, Virmani R. The pathology of neoatherosclerosis in human coronary implants: bare metal and drug-eluting stents. Journal of the American College of Cardiology. 2011; 57(11), Neff LP, Tillman BW, Yazdani SK, Machingal M, Yoo JJ, Soker S, Bernish B, Geary RL, Christ GJ. Vascular smooth muscle enhances functionality of tissue engineered blood vessels in vivo. Journal of Vascular Surgery. 2011; 53(2), Yazdani SK, Nakano M, Otsuka F, Kolodgie FD, Virmani R. Atheroma and coronary bifurcations: before and after stenting. EuroIntervention. 2010; 6, J Vorpahl M, Yazdani SK, Nakano M, Ladich E, Kolodgie FD, Finn AV, Virmani R. Pathobiology of stent thrombosis after drug-eluting stent implantation. Current Pharmaceutical Design. 2010; 16(36), Reifart N, Gyongyosi M, Hauptmann KE, Rabe A, Enayat D, Giokoglu K, Kolodgie FD, Vorpahl M, Yazdani SK, Hemetsberger R, Samaha E, Pavo IJ, Virmani R. Pre-clinical and clinical study results for the Coracto TM Rapamycineluting stent A new-generation drug-eluting stent. Interventional Cardiology. 2010; 5, Yazdani SK, Vorpahl M, Ladich E, Virmani R. Pathology and vulnerability of atherosclerotic plaque: Identification, treatment options, and individual patient differences for prevention of stroke. Current Treatment Options in Cardiovascular Medicine. 2010; 12, Nakazawa G, Yazdani SK, Finn AV, Kolodgie FD, Virmani R. Pathological findings at bifurcation lesions: The impact of flow distribution on atherosclerosis and arterial healing following stent implantation. Journal of the American College of Cardiology. 2010; 55, of 9 30. Bekkers S, Yazdani SK, Virmani R, Waltenberger J. Microvascular obstruction: Underlying pathophysiology and clinical diagnosis. Journal of the American College of Cardiology. 2010; 55, Yazdani SK, Tillman BW, Berry JL, Soker S, Geary RL. The fate of an endothelium layer after preconditioning: An in vitro and in vivo analysis. Journal of Vascular Surgery. 2010; 51, Yazdani SK, Watts B, Machingal M, Jarajapu Y, Van Dyke ME, Christ GJ. Smooth muscle cell seeding of decellularized scaffolds: The importance of bioreactor preconditioning to development of a more native architecture for tissue engineered blood vessels. Tissue Engineering Part A. 2009; 15, Tillman BW, Yazdani SK, Corriere M, Geary RL, Atala A, Yoo JJ. Efficient recovery of endothelial progenitors for clinical translation. Tissue Engineering Part C. 2009; 15, Yazdani SK, Berry JL. The development of an in vitro system to assess stent induced smooth muscle cell proliferation: a feasibility study. Journal of Vascular Interventional Radiology. 2009; 20, Tillman BW, Yazdani SK, Lee SJ, Geary RL, Atala A, Yoo JJ. The in vivo stability of electrospun polycaprolactonecollagen scaffolds in vascular reconstruction. Biomaterials. 2009; 30, Whitlow CT, Geer CP, Mattern CW, Mussat-Whitlow BJ, Yazdani SK, Berry JL, Lalli JH, Claus RO, Challa VR, Morris PP. Endovascular histologic effects of ultrathin gold-or vitronectin-coated platinum aneurysm coils in a rodent arterial occlusion model: a preliminary investigation. American Journal of Neuroradiology. 2009; 30, Whitlow CT, Yazdani SK, Reedy ML, Kaminsky SE, Berry JL, Morris PP. Investigating sacroplasty: Technical considerations and biomechanical properties of polymethylmethacrylate infusion into cadaveric sacrum. American Journal of Neuroradiology. 2007; 28, Amiel G, Komura M, Shapira O, Yoo J, Yazdani S, Berry JL, Kaushal S, Bischoff J, Atala A, Soker S. Engineering of Blood Vessels from Acellular Collagen Matrices Coated with Human Endothelial Cells. Tissue Engineering. 2006; 12, Yazdani SK, Berry JL, Moore J, Vlachos PP. DPIV Measurements of Flow Disturbances in Stented Artery Models: Importance of Compliance Mismatch. Journal of Biomechanical Engineering. 2004; 126, Invited Commentaries and Articles 1. Nakano M, Yazdani SK, Virmani R. The Present State of Drug-Coated Balloons. Cardiology Today Intervention. December Yazdani SK, Otsuka F, Nakano M, Finn AV, Virmani R. Do animal models of vein graft atherosclerosis predict outcomes in man? Atherosclerosis. 2012; 223(1): Yazdani SK, Kolodgie FD, Virmani R. Atherosclerotic Disease at Coronary Bifurcations and the Impact of Stenting. International Atherosclerosis Society. April Book Chapters 1. Nakano M, Kolodgie FD, Otsuka F, Yazdani SK, Ladich ER, Carter-Monroe N, Finn AV, Virmani R. Vulnerable Plaque. Coronary Heart Disease: Clinical, Pathological, Imaging and Molecular Profiles. Springer, New York, NY, Machingal MA, Yazdani SK, Christ GJ. Engineering of Large Diameter Vessels. Principles of Regenerative Medicine. Second Edition. Elsevier, Burlington, MA, Yazdani SK, Ladich E, Virmani R. Pathology of Myocardial Ischemia, Infarction, Reperfusion, and Sudden Death. Hurst s The Heart, 13 th Edition. McGraw-Hill, New York, NY, Nakano M, Vorpahl M, Yazdani S, Ladich E, Kuts R, Kolodgie FD, Finn AV, Virmani R. The Thrombotic AMI Lesion: Lessons from Pathology. Textbook of STEMI Interventions, 2 nd Edition. HMP Communications. Malvern, PA, Carter-Monroe N, Yazdani SK, Ladich E, Kolodgie FD, Virmani R. Introduction to the Pathology of Carotid Atherosclerosis: Histologic Classification and Imaging Correlation. In Atherosclerosis Disease Management. Atherosclerosis disease. Springer, New York, NY, of 9 6. Nakano M, Vorpahl M, Yazdani S, Kolodgie FD, Finn AV, Virmani R. Structure of Stable and Vulnerable Atheromatous Plaques. Coronary Stenosis: Imaging, Structure and Physiology. Europa Edition, Toulouse, France, Yazdani SK, Christ GJ. Engineering of Large Diameter Vessels. Principles of Regenerative Medicine. Elsevier, Burlington, MA, Abstracts and Conference Papers 1. Turner E, Marzieh A, Yazdani SK. Pharmacokinetic Evaluation of Non-Stent Drug Delivery: An In Vitro System For Rapid Evaluation, NCVH 2015, May 27-29, New Orleans, LA. 2. Turner E, Marzieh A, Christians U, Yazdani SK. Ex vivo system for pharmacokinetic analysis of catheter-based, vascular drug delivery. 31st Annual Southern Biomedical Engineering Conference, 2015, May 1-2, New Orleans, LA. 3. Carroll N, Morrison J, Gould E, Kim SH, Yazdani SK. Efficacy of a Real-Time Optical Measurement System. 31st Annual Southern Biomedical Engineering Conference, 2015, May 1-2, New Orleans, LA. 4. Turner E, Tomblyn S, Burnett L, Yazdani SK. Keratose as a novel drug carrier for drug coated balloons. Society for Biomaterials Annual Meeting, 2015, April 15-18, Charlotte, NC. b 5. Moore G, Yazdani SK. An in vitro model of endothelialized scaffolds to assess the impact of varying stiffness. Annual Biomedical Research Conference for Minority Students, 2014, November 11-14, San Antonio, TX. 6. Atigh M, Yazdani SK. Pharmacokinetic Evaluation of Non-Stent Drug Delivery: An In Vitro System For Rapid Evaluation. BMES Annual Meeting, 2014, October 22-25, San Antonio, TX. 7. Yazdani SK, Atigh M, Kim SH, Finet J, Pettigrew RI, Ohayon J. An original endothelialized coronary bifurcation model to investigate pathologic mechanisms underlying coronary atherosclerotic disease. 7th World Congress of Biomechanics, 2014, July 6-11, Boston, MA. 8. Huot A, Yazdani SK. Finite element analysis of arterial vessel wall stiffness. 30th Annual Southern Biomedical Engineering Conference, 2014, April 11-12, Gulfport, MS. (Journal of the Mississippi Academy of Sciences. 2014; 59 (Supl.), ) 9. Turner E, Tomblyn S, Burnett L, Yazdani SK. Keratin as a novel drug carrier for drug coated balloons. 30th Annual Southern Biomedical Engineering Conference, 2014, April 11-12, Gulfport, MS. (Journal of the Mississippi Academy of Sciences. 2014; 59 (Supl.), ) 10. Parks A, Yazdani SK. Development of silicone coronary bifurcation models for in vitro flow evaluation. 30th Annual Southern Biomedical Engineering Conference, 2014, April 11-12, Gulfport, MS. (Journal of the Mississippi Academy of Sciences. 2014; 59 (Supl.), ) 11. Gould E, Carroll N, Jefferson GD, Yazdani SK. Development of a three-dimensional digital image correlation for displacement and strain measurement of seeded endothelial cells. 30th Annual Southern Biomedical Engineering Conference, 2014, April 11-12, Gulfport, MS. (Journal of the Mississippi Academy of Sciences. 2014; 59 (Supl.), ) 12. Carroll N, Yazdani SK. Development of a novel bench-top model to mimic the lower extremity arteries and stent mechanics. 30th Annual Southern Biomedical Engineering Conference, 2014, April 11-12, Gulfport, MS. (Journal of the Mississippi Academy of Sciences. 2014; 59 (Supl.), ) 13. Atigh MK, Smith K, Yazdani SK. Endothelialized in vitro tubular silicone scaffolds. 30th Annual Southern Biomedical Engineering Conference, 2014, April 11-12, Gulfport, MS. (Journal of the Mississippi Academy of Sciences. 2014; 59 (Supl.), ) 14. Marzieh A, Yazdani SK. Development of an in vitro system for rapid evaluation of cardiovascular devices, NCVH 2013, June 5-7, New Orleans, LA. 15. Sojitra P, Yazdani S, Otsuka F, Doshi M, Kolodgie F, Virmani R. A Novel Nano Particle Sirolimus Delivery Via Coated Balloon. Cardiovascular Research Technologies, 2013, February 23-26, Washington, DC. 5 of 9 16. Yazdani SK, Kolodgie FD, Virmani R, Vascular Response to Treatment with a Paclitaxel Coated Balloon in a Preclinical Femoral Artery Model , BMES 2012 Annual Meeting, October 24-27, Atlanta, GA. 17. Sheehy A, Yazdani S, Berger E, Donn RS, Ngo TD, Pacetti S, Hossainy S, Kolodgie FD, Virmani R, Pharmacokinetic Evaluation of Drug Eluting Stents in a Healthy and Atheroclerotic Rabbit Iliac Model, Transcatheter Cardiovascular Therapeutics, 2011, November 7-11, San Francisco, CA. (Journal of the American College of Cardiology. 2011;58;B124-B125) 18. Yazdani SK, Nakano M, Sherdiwala DP, Doshi M, Sojitra PN, Kolodgie FD, Virmani R, A Temporal Assessment of Drug Distribution Following Local Balloon Delivery of Nanoparticle Sirolimus, Transcatheter Cardiovascular Therapeutics, 2011, November 7-11, San Francisco, CA. (Journal of the American College of Cardiology. 2011;58;B56) 19. Sheehy A, Yazdani S, Berger E, Donn RS, Ngo TD, Pacetti S, Hossainy S, Kolodgie FD, Virmani R, Evaluation of Drug Tissue Concentration Following Stenting in a Healthy Rabbit Iliac Model, Transcatheter Cardiovascular Therapeutics, 2011, November 7-11, San Francisco, CA. (Journal of the American College of Cardiology. 2011;58;B124) 20. Yazdani SK, Su S, Shulze J, Kolodgie FD, Virmani R, Endothelialization of Polymer-Free Drug-Coated Stents, Euro PCR, 2011, May 17-20, Paris, France. (EuroIntervention. 2011; Vol. 7, Suppl M) 21. Yazdani SK, Parker S, Rowland S, Ligtenberg E, Kolodgie FD, Virmani R, Anti-CD34 Stent Surface Modification Reduce Thrombogenicity and Increase Endothelialization, Euro PCR, 2011, May 17-20, Paris, France. (EuroIntervention. 2011; Vol. 7, Suppl M) 22. Yazdani SK, Pacheco E, Monroe NC, Kolodgie FD, Virmani R, A Novel Polymer Coating for Drug Eluting Stent Applications, American College of Cardiology & i2 Summit, 2011, April 2-5, New Orleans, LA. (Journal of the American College of Cardiology. 2011; 5:E1664) 23. Otsuka F, Nakano M, Yazdani SK, Ladich E, Kolodgie FD, Finn AV, Virmani R, Are Stent Related and Non-Stent Related Deaths Different Between Drug-Eluting Stents and Bare Metal Stents? A Pathologic Study, American College of Cardiology & i2 Summit, 2011, April 2-5, New Orleans, LA. (Journal of the American College of Cardiology. 2011; 57:E1647) 24. Nakano M, Otsuka F, Yazdani SK, Finn AV, Kolodgie FD, Jagat N, Virmani R, Histomorphometric Characteristics of High-Risk Plaques, American College of Cardiology & i2 Summit, 2011, April 2-5, New Orleans, LA. (Journal of the American Col
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