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Ser Unit4notePart3Strep

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  Unit 4 Part 3 Streptococcal Serology Terry Kotrla, MS, MT(ASCP)BB  Introduction  Gram-positive  Beta hemolytic  Spherical, ovoid or lancet shaped  Pairs or chains  Divided into Serotypes or groups  Two major outer proteins M and T  Interior proteins divided into 20 defined groups known as Lancefield groupings A-H and K-T.   Streptococcus pyogenes  belong to Lancefield group A  M protein chief virulent factor  Numerous Exoantigens  Exoantigens are produced and excreted and include:  Streptolysin O  Dnase  Hyaluronidase  Nicotinamide Adenine Dinucleotidase  Streptokinase  Patients react to exoantigens by producing antibodies
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