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  THERAPY WORKSHEET: page 1 of 2 Title of the article : ……………………………………….First athors: ……………………………………….!or al: ………………………………………. A. #A$%&%TY: Are the reslts of this si gle pre'e ti'e or therapetic trial 'ali() Was the assignment of patients to treatments randomised? ã and was the randomisation list concealed?Were all patients who entered the trial accounted for at its conclusion? ã and were they analysed in the groups to which they were randomised?Were patients and clinicians kept “blind” to which treatment was being received? Aside from the experimental treatment, were the groups treated equally?Were the groups similar at the start of the trial?   THERAPY WORKSHEET* PA+E 1 OF 2  ccurrence of diabetic neuropathy!elative !isk!eduction!!! Absolute !isk!eduction A!! umber eededto #reat #$sual %nsulin&ontrol 'vent!ate&'!%ntensive%nsulin'xperimental'vent !ate''!&'! ( ''!&'!&'! ( ''!)*A!!+-./0.+-. ( /0. 12). +-.+-. ( /0. 1-0.345. to +5.6)*-0. 1 )7pts,3)) to /56 ,. %-PORTA/ESa0ple calclatio s 8 3 /o fi(e ce % ter'al 4/%5 o a T 6 1 7 4li0its o the /% of its ARR5 6  Yor calclatio s 8!elative !isk!eduction!!! Absolute !isk!eduction A!! umber eededto #reat #&'!''!&'! ( ''!&'!&'! ( ''!)*A!! THERAPY WORKSHEET: page 2 of 2 /. APP$%/A,%$%TY: /a 8o appl8 this 'ali(9 i0porta t e'i(e ce aot a treat0e t i cari g for 8or patie t) 1. Do these results apply to your patient?  %s your patient so different from thosein the trial that its results can9t help you?:ow great would the potential benefitof therapy actually be for your individual patient?;ethod %8 ff   1 !isk of the outcome in your patient, relative to patients in the trial expressed as adecimal 1 <<< # for patients like yours 1 #*f 1 <* <1 <<<;ethod %%8  1 7 4PEER ; RRR5PEER 1 =our patient9s expected event rate if they received the control treatment 1 << 3 # for patients like yours6 1 ) * 3>''! x !!!6 1 )* <<<<1 <<< 2. Are your patient’s values and preferences satisfied by the regimen and its consequences?  o your patient and you have a clear assessment of their values and preferences? Are they met by this regimen and its  consequences? A((itio al otes:  SYSTE-AT%/ RE#%EW 4of Therap85 WORKSHEET: page 1 of 2/itatio :Are the reslts of this s8ste0atic re'ie< of therap8 'ali() %s it a systematic review of randomised trials of the treatment you9re interested in?oes it include a methods section that describes8finding and including all the relevant trials?assessing their individual validity?Were the results consistent from study to study? Are the 'ali( reslts of this s8ste0atic re'ie< i0porta t) #ranslating odds ratios to #s #he numbers in the body of the table are the #s for the corresponding odds ratios at that particular patient9s expected event rate 3>''!6dds !atios 3!6@+@07@0@27@2@-7@-@77@7@7/@+ ) )5+)@405-+7+7/4-4) / )@))@2574455-5)/2/4/)&ontrol/@-)4@5@/4/@)2)4)5))'vent5@4-5@//)0)4)/)@+0!ate4@4@/-)+)7)/)@+023&'!67@ 5 50/7)0)4))+02-2@44/0/@)-)5)@+2-+@)@) 4 -44-54/2//)0)7)/ 7)  #he relative risk reduction 3!!!6 here is )@. /  #he !!! here is 4+. 5  or any !, # is lowest when >''! 1 7@ 4  #he !!! here is ). 7  #he !!! here is +.
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